Document Type: Article All Authors / Contributors: Abusaris H.; Hoogeman M.; Nuyttens J.J. ISSN:1533-0346 Language Note: English Unique Identifier: 817841585 Awards:
| Title | : | Re-irradiation: Outcome, cumulative dose and toxicity in patients retreated with stereotactic radiotherapy in the abdominal or pelvic region |
| Author | : | Abusaris H.; Hoogeman M.; Nuyttens J.J. |
| Language | : | en |
| Rating | : | 4.90 out of 5 stars |
| Type | : | PDF, ePub, Kindle |
| Uploaded | : | Apr 12, 2021 |
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High-dose re-irradiation results in median overall survival of about 17 months in selected patients, with median time to progression of about 10 months. A small proportion of patients could possibly even be cured with this approach, since there are a few patients without recurrence at follow-up.
Re-irradiation: outcome, cumulative dose and toxicity in patients retreated with stereotactic radiotherapy in the abdominal or pelvic region. Huda abusaris department of radiation oncology, erasmus mc- daniel den hoed cancer center, rotterdam, the netherlands.
The purpose of the present study was to explore the outcome, cumulative dose in tumor and organs at risk and toxicity after extra-cranial stereotactic re-irradiation. Twenty-seven patients were evaluated who had been re-irradiated with stereotactic body radiotherapy (sbrt) after conventional radiotherapy (crt). The dose summation of the sbrt and crt plans was done by dose point calculations.
Jun 19, 2019 outfield progression was defined as recurrence or progression of the disease outside the re-irradiation field.
Aug 7, 2020 the basis of their study is the total cumulative carbon dioxide (co₂), outcomes based on the global trend with respect to climate change.
Total doses of re-irradiation were prescribed at the discretion of the radiation oncologist, who considered the cumulative dose between initial radiation and re-irradiation, re-irradiation target volume, and patient performance.
Unlabelled: the purpose of the present study was to explore the outcome, cumulative dose in tumor and organs at risk and toxicity after extra-cranial stereotactic re-irradiation.
Re-irradiation for recurrent gliomas: treatment outcomes and prognostic factors. Practical radiation oncology, 2015 postoperative radiation therapy for osseous metastasis: outcomes and predictors of local failure.
Changes in the dose frequency and treatment length do not alter the total exposure to radiation and, as a result, the long-term effects remain similar.
The median cumulative dose for the rectum, bowel and bladder resulted in 104 gy3, 98 gy3 and 113 gy3, respectively. In conclusion: re-irradiation to the same region using extra-cranial stereotactic radiotherapy is feasible and resulted in a 96% symptomatic response with low toxicity.
Jan 8, 2019 re-irradiation with cumulative doses higher than first-line tolerance, might result in a higher risk of reduced blood perfusion and tissue.
In this series, despite limiting the re-irradiation volume to the gross disease, only 4% of the patients had a recurrence outside of the irradiated area. Minimizing the amount of tissue re-irradiated diminishes the probability of side effects.
As there are no guidelines regarding the dose schemes for re-irradiation, available published data on this subject is very heterogeneous, especially with regards to dose fractionation and cumulative doses applied this also applies to the current analysis: depending on total dose in the first rt, modality of the radiation, location.
Dec 17, 2019 the biologically effective dose (bed) was calculated and the results are discussed reirradiation, it is necessary to consider whether the dose of tolerance cumulative bed where no case of radiation myelopathy (rm).
Re-irradiation is being increasingly considered as an option, in view of the advances in treatment techniques, the ability to document doses and overlay plans. However, there is lack of data on outcomes, cumulative doses and prognostic factors in re-irradiation of gliomas.
In this activity you will explore the main factors influencing radiation sensitivity. You will also consider the knowledge about hypoxia, reoxygenation, tumour cell.
Re-irradiation outcome cumulative dose and toxicity in patients retreated with stereotactic radiotherapy in the abdominal or pelvic region.
Expected outcome with re-irradiation in head and neck cancers the median os expected from re-irradiation may vary from 10 to 12 month, with a 2 year overall survival ranging from 37% to 58% in various reported trials. the overall survival may be slightly higher for patients who underwent re-irradiation in the postoperative setting with a range of 12–16 months. the 2 year local control that may be expected from re-irradiation may be in the range 40–64%.
Sbrt dose was 30 gy in 5 fractions, daily or alternate days, using cumulative organ at risk dose constraints.
Based on recent reports, a growing number of radiation oncologists are using cumulative bed distributions to guide their re‐irradiation plan evaluation. 3, 6 several institutions have reported oar toxicity along with cumulative bed metrics in lung cancer patients receiving re‐irradiation, 9, 10 with some instances of severe toxicities after.
Dec 13, 2019 results: the median maximum cumulative equivalent doses applied in fractions of 2 gy (eqd2) to the brainstem, optic chiasm, ipsilateral optic.
Keywords: re-irradiation, rectal cancer, locoregional recurrence, acute toxicity, late toxicity. Citation: chung sy, koom ws, keum kc, chang js, shin sj, ahn jb, min bs, lee ky, kim nk and yoon hi (2019) treatment outcomes of re-irradiation in locoregionally recurrent rectal cancer and clinical significance of proper patient selection.
Although there is still no standard treatment for recurrent glioblastoma multiforme (rgbm), re-irradiation could be a therapeutic option.
Cumulative dose, toxicity, and outcomes of spinal metastases re-irradiation: systematic review on behalf of the re-irradiation working group of the italian association of radiotherapy and clinical.
Re-irradiation studies in the head and neck up to total cumulative doses of 120 gy reported grade 2 and 3 late toxicities in the form of cervical fibrosis (41%) and mucosal necrosis (21%). [23] the tolerance of skin and mucosal acute effects seems to be tolerable in the dose range of 110–120 gy eqd2, with slightly higher incidence of late.
Jun 25, 2018 the cumulative life time dose to organs like the spinal cord, brain stem and long-term outcome of concurrent chemotherapy and reirradiation.
/ the role of hyperfractionated re-irradiation in the influence of hyperfractionation on the outcome needs.
Re-irradiation of bone metastases is safe and effective with response rates varying from 33% to 84% in retrospective studies using a variety of dose/fractionation regimens [21]. Cumulative radiation doses to critical normal structures must be considered carefully, as in all re-irradiation scenarios.
Symptomatic responses were obtained without clinically relevant side effects.
Need to be considered for re-irradiation, tissue recovery and dose tolerances in the setting of outcome, cumulative dose and toxicity in patients retreated.
Cumulative dose, toxicity, and outcomes of spinal metastases re-irradiation systematic review on behalf of the re-irradiation working group of the italian association of radiotherapy and clinical oncology (airo) zeitschrift: strahlentherapie und onkologie autoren:.
Re-irradiation for palliative treatments with low to ac-ceptable probability of radiation necrosis. Aim of this retrospective study was to determine dif-ferent treatment parameters of re-irradiation such as maximum dose, mean dose, treated volume, eud as well as their cumulative estimates and correlate these parameters with survival.
Mar 7, 2021 re-irradiation: outcome, cumulative dose and toxicity in patients retreated with stereotactic radiotherapy in the abdominal or pelvic region.
Nov 21, 2019 four patients had breast cancer recurrence, with a 5-year cumulative therefore the results demonstrated that partial breast reirradiation.
Doses and overlapping volumes in re-irradiation for head and neck cancer study was to evaluate the treatment outcome after re-irradiation for hnc and determine some predictive factors, including cumulative dose-volume parameters.
First, deb- mentioned above, the treatment options for these patients ulking surgery before re-irradiation results in better outcomes are limited.
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