Document Type: Article All Authors / Contributors: H Im; J N Sutherland; J A Maynard; S -H Oh ISSN:0003-2700 BL Shelfmark:0897.000000 Language Note: English Unique Identifier: 782094089 Awards:
| Title | : | Nanohole-Based Surface Plasmon Resonance Instruments with Improved Spectral Resolution Quantify a Broad Range of Antibody-Ligand Binding Kinetics |
| Author | : | H Im; J N Sutherland; J A Maynard; S -H Oh |
| Language | : | en |
| Rating | : | 4.90 out of 5 stars |
| Type | : | PDF, ePub, Kindle |
| Uploaded | : | Apr 12, 2021 |
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We investigated a structure for surface plasmon-polariton-based chemical sensing consisting of a square 2d lattice of circular nanoapertures drilled in a plasmonic material on a dielectric substrate. Contrary to the usual approach, we did not consider opaque metal slabs, but instead investigated a thin film of transparent conductive oxide (tco) as the plasmonic part.
Plasmon line shaping using nanocrosses for high sensitivity localized surface plasmon resonancesensing.
Nanohole based plasmonic sensors have recently taken much interest due to their ultra-small interrogation volumes and (near) collinear illumination settings. Normal excitation of spps in nanohole arrays holds the promise for massive multiplexing and easy lab-on-chip integration.
May 3, 2018 keywords: plasmonics, surface plasmon polariton, extraordinary optical transmission, a novel approach to achieving polarization conversion based on spps role of polarization in spp excitation on nanohole arrays.
Here is the surface-plasmon wavecetor, incident-light wave vector in-x direction (parallel to the metal surface), θ is the angle of incidence to the surface normal, (i,j) is the grating order for reciprocal lattice vector and of the square lattice (, p is the periodicity).
Surface plasmon resonance platforms, based on arrays of nanoholes on gold films, were used to detect the binding of organic and biological molecules. Optical sensors were assembled using nanohole arrays with different resonance energies, tuned by adjusting the distance between the holes.
1 transmission and reflection mode for nanohole array sensors 39 it is based on the dependence of surface plasmon resonance upon dielectric.
Nanohole arrays exhibit a series of advantages over conventional spr-based sensors. First of all, since these periodic systems do not require additional prisms to excite the plasmonic modes, they can be more easily miniaturized and integrated in nanoscale devices.
In sers, the raman signal of target molecules is amplified through excitations of localized surface plasmon resonances (lsprs) due to the related supports (or substrates), which are generally utilized in the form of individual metallic nanostructures, coupled metallic nanostructures, or roughened metal films on various substrates [8–10.
In this presentation, we explore the feasibility of plasmonic nanohole-based sub-diffraction-limited nanoscopy for biomolecular imaging. The technique utilizes near-field distribution localized by surface plasmon localization on metallic nanoholes which is used to sample molecular fluorescence.
In surface plasmon polariton (spp) sensing, nanohole films can be used in two configurations to sense molecules in a water solution. In the reflection mode (top), light is directed at the sample from the water side. In the transmission mode (bottom), it is directed at the sample from the back, leading to different spp properties.
We show the spectral figure-of-merit (fom) from nanohole arrays can be larger than 1900/riu by phase-based surface plasmon resonance.
Oh, “nanohole-based surface plasmon resonance instruments with improved spectral resolution quantify a broad range of antibody-ligand binding kinetics,” anal.
May 27, 2015 plasmonic devices such as plasmonic waveguide [1–3] and bio- or chemical sensors based on localized or propagating surface plasmon.
Nanohole-based surface plasmon resonance instruments with improved spectral resolution quantify a broad range of antibody-ligand binding kinetics.
This system relies on nanohole-based surface plasmon resonance (spr) technique. The chip is formed nanoholes with a diameter of 200 nm in a thin (100 nm) golden film. The chip surface is coated with specific antibody as elisa, and an obvious signal shift will be detected once the double antibody sandwich (antibody-protein-antibody-aunps) forms.
Plasmonic nano-hole arrays are an interesting avenue of research because of incorporating the already strong light-matter interaction of surface plasmons.
15,16 one example of this approach is to use nanosphere lithography to create uniform arrays of surface-bound particles that are highly sensitive to their immediate surrounding dielectric environment. 17 nanohole-based systems have also been studied with specific.
In this article, we improve the resolution of the nanohole array configuration.
6×10−6 refractive index units is achieved, which is comparable to surface plasmon resonance system based on the kretchmann configuration.
Applied nanohole-based surface plasmon resonance for the detection of transmembrane (epcam and cd63) and intravesicular (akt1) proteins contained in exosomes’ lysates. The exosomes originated from three ovarian cancer cell lines and one benign cancer cell line.
The technique utilizes near-field distribution localized by surface plasmon localization on metallic nanoholes which is used to sample molecular fluorescence. The optimum geometry of nanohole arrays was determined by numerical analysis.
Nanohole-based surface plasmon resonance instruments with improved spectral resolution quantify a broad range of antibody-ligand binding kinetics h im, jn sutherland, ja maynard, sh oh analytical chemistry 84 (4), 1941-1947 2012.
Fingerprint dive into the research topics of 'nanohole-based surface plasmon resonance instruments with improved spectral resolution quantify a broad range of antibody-ligand binding kinetics'.
Facilitating flow-through sensing is, however, more complicated than flow-over which can be achieved with a single fluidic channel. For a given application the potential benefit offered by flow-through sensing will be a function of operating parameters and binding kinetics of the specific analyte.
Niwa, “electrochemical surface plasmon resonance measurement based on gold nanohole array fabricated by nanoimprinting technique,” anal.
The nanohole-based spr devices measure transmission of normally-incident light and the co-linear optical transmission setup offers simple optical setup and high-resolution imaging capability, leading to high-throughput multiplex kinetic assays for protein microarray applications.
The nanohole-based optofluidic platform demonstrated here is straightforward to construct, applicable to both charged and neutral molecules, and performs a novel function that cannot be accomplished using conventional surface plasmon resonance sensors.
Im h, sutherland jn, maynard ja, oh s-h (2012) nanohole-based surface plasmon resonance instruments with improved spectral resolution quantify a broad range of antibody-ligand binding kinetics. Anal chem 84:1941–1947 crossref pubmed pubmedcentral google scholar.
The key advantage of nanohole-based spr setup is that plasmons can be excited at normal incidence, which enables simple optical alignment and high-resolution imaging. Using template stripping technology, massively parallel and highly homogenous nanohole arrays, which is the prerequisite to perform high-throughput spr imaging, are obtained over.
Nanohole-based surface plasmon resonance instruments with improved spectral resolution quantify a broad range of antibody-ligand binding kinetics february 2012 analytical chemistry 84(4):1941-7.
Surface plasmon resonance biosensor technology has enjoyed rapid development in the past two decades and undergone a boom in recent years. The growing demand for analytical applications has brought a variety of these instruments on to the market, and these sensors are nearly essential in the biochemical analysis laboratory, with wide applications in the life sciences, environmental monitoring.
In this paper, we demonstrate a compact integrated nanohole array-based surface plasmon resonance sensing device. The unit includes a led light source, driving circuitry, ccd detector, microfluidic network and computer interface, all assembled from readily available commercial components.
Oct 21, 2013 we have developed a fabrication approach based on self assembly of nanostructures, which lets us precisely control the surface texture.
Correction: copper and gold actually have plasma frequencies higher than the visible range, so this.
Keywords: surface plasmon resonance, label-free biosensing, nanohole array. Introduction previous work demonstrated spr measurements using periodic nanohole arrays and a fiber-optic spectrometer [2,3]. In this work, we demonstrate nanohole-based multiplex spr sensing using a hene laser and a ccd imager integrated with microfluidics.
Surface plasmons in the visible and near infrared range are copper, gold and silver [12–14]. The excitation of surface plasmons in nanometer-sized curved metallic structures (like gold nanoparticles [15] and gold nanorods [16]) generate localized plasmon resonance (lspr) [17,18]. On the other hand, surface plasmons excited in planar surfaces.
Matching surface plasmon modes in symmetry-broken structures for nanohole-based color filter yun seon do kyung cheol choi publication year: 2013 page (s) 2454 - 2457.
Other groups have developed sensors based on nanohole arrays in metal films. These sensors detect molecules via a phenomenon called surface plasmon resonance.
This paper reports a new nanofluidic plasmonics-based sensing platform which can be readily integrated with microfluidics devices, and potentially enable an in-parallel transmission surface plasmon resonance (spr), lab-on-chip sensing technology.
14-17 alternatively, a metal can be directly deposited on the ps spheres to make a film-over-nanosphere (fon) structure. 18,19 among the patterns created by nsl,20-36 au nanohole arrays have the most versatility, supporting both localized and propagating surface plasmons resonances.
Oh, “ sub-micron resolution surface plasmon resonance imaging enabled by nanohole arrays with surrounding bragg mirrors for enhanced sensitivity and isolation,” lab chip 9, 382 (2009).
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