Full Download Effect of membrane dialysis on characteristics of lyophilised chitosan wafers for potential buccal delivery of proteins. - I Ayensu Affiliation: Department of Pharmaceutical, Chemical and Environmental Sciences, School of Science, University of Greenwich at Medway, Chatham Maritime, Kent, UK.; JC Mitchell; JS Boateng file in ePub Online

Read Online Effect of membrane dialysis on characteristics of lyophilised chitosan wafers for potential buccal delivery of proteins. - I Ayensu Affiliation: Department of Pharmaceutical, Chemical and Environmental Sciences, School of Science, University of Greenwich at Medway, Chatham Maritime, Kent, UK.; JC Mitchell; JS Boateng | PDF

Document Type: Article All Authors / Contributors: I Ayensu Affiliation: Department of Pharmaceutical, Chemical and Environmental Sciences, School of Science, University of Greenwich at Medway, Chatham Maritime, Kent, UK.; JC Mitchell; JS Boateng ISSN:0141-8130 Language Note: English Unique Identifier: 792886121 Awards: Abstract: The effect of membrane dialysis on the characteristics of chitosan based lyophilised wafers was investigated. Gels loaded with BSA, glycerol and d-mannitol were lyophilised with or without membrane dialysis and characterised by X-ray diffraction, attenuated total reflectance Fourier transform infra red spectroscopy, circular dichroism, scanning electron microscopy, hydration capacity, in vitro mucoadhesivity and drug dissolution. The dialysed wafers demonstrated enhanced mucoadhesion and drug release properties while newly formed sodium acetate in the undialysed wafers caused increased crystallinity with poor mucoadhesion and drug release properties. Removal of sodium acetate by membrane dialysis is essential for obtaining optimised wafers for potential application to the buccal mucosa surface.

Title : Effect of membrane dialysis on characteristics of lyophilised chitosan wafers for potential buccal delivery of proteins.
Author : I Ayensu Affiliation: Department of Pharmaceutical, Chemical and Environmental Sciences, School of Science, University of Greenwich at Medway, Chatham Maritime, Kent, UK.; JC Mitchell; JS Boateng
Language : en
Rating :
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Type : PDF, ePub, Kindle
Uploaded : Apr 12, 2021

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