Read Online Superior prognostic importance of perineural invasion vs. lymph node involvement after curative resection of duodenal adenocarcinoma. - S Cecchini Affiliation: Department of Surgery, Massachusetts General Hospital, Boston, MA, USA.; C Correa-Gallego; V Desphande; M Ligorio; A Dursun; All authors | PDF Online

Document Type: Article All Authors / Contributors: S Cecchini Affiliation: Department of Surgery, Massachusetts General Hospital, Boston, MA, USA.; C Correa-Gallego; V Desphande; M Ligorio; A Dursun; J Wargo; Fernàndez-del Castillo C; AL Warshaw; CR Ferrone ISSN:1091-255X Language Note: English Unique Identifier: 776307823 Awards: Abstract: BACKGROUND: Unlike other gastrointestinal tumors, lymph node involvement has not consistently been a negative prognostic factor for survival in patients with duodenal adenocarcinoma. Our aim is to examine prognostic factors in patients who underwent a curative resection of their duodenal adenocarcinoma. METHODS: A retrospective review of 169 patients diagnosed with primary duodenal lesions between 1982 and 2010 was performed, of whom 103 were treated with curative intent. Clinico-pathologic factors were evaluated. RESULTS: A potentially curative resection was performed in 103 patients with a median age of 67 years (range, 22-91). Perineural and lympho-vascular invasion were identified in 30 (29.1%) and 39 patients (37.9%), respectively. Median follow-up was 26.5 months. The 5-year overall survival was 62% vs. 25% for patients with or without nodal metastases (p