Document Type: Article All Authors / Contributors: Perus O.; Ramain E.; Raucoules-Aime M.; Marsot A.; Simon N.; Dahman M.; Paci A. ISSN:0007-0912 Language Note: English Unique Identifier: 811696619 Awards:
| Title | : | Performance of alfentanil target-controlled infusion in normal and morbidly obese female patients |
| Author | : | Perus O.; Ramain E.; Raucoules-Aime M.; Marsot A.; Simon N.; All authors |
| Language | : | en |
| Rating | : | 4.90 out of 5 stars |
| Type | : | PDF, ePub, Kindle |
| Uploaded | : | Apr 12, 2021 |
Read Performance of alfentanil target-controlled infusion in normal and morbidly obese female patients - Perus O.; Ramain E.; Raucoules-Aime M.; Marsot A.; Simon N.; All authors file in PDF
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Fast diffusion of alfentanil into vascular spaces occurred and produced concentrations of approximately 10ng ml-1 from 10 minutes up to the end of the study at 24 hours. Between 12 and 24 hours, csf concentrations of alfentanil declined and were almost identical to plasma concentrations.
Fentanyl, alfentanil, sufentanil, and remifentanil are used in surgical been used as have high-performance liquid chromatography.
Alfentanil medical labels are designed for optimum performance in any medical environment. These labels are recommended for surgical centers and hospitals. This medical label is made with aggressive permanent adhesive with a service temperature ranging from -65 to 220 fahrenheit.
Laryngoscopy and tracheal intubation often cause hypertension and tachycardia, which may be exaggerated during rapid-sequence induction of anaesthesia. A placebo-controlled,doubleblind study was conducted in 60 patients to determine doseresponse and effects on myocardial performance of alfentanil when used to attenuate this cardiovascular response.
Alfentanil (alfenta) • chronic alcohol consumption may increase the risk of pharmacodynamic tolerance to alfentanil. • consider higher doses of alfentanil in patients who regularly consume alcohol. Long-acting morphine (kadian 6, avinza 7) • increased morphine release rate.
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Free online library: effects of alfentanil or fentanyl added to propofol for sedation in colonoscopy on cognitive functions: randomized controlled trial. (original article) by the turkish journal of gastroenterology; health, general colonoscopy analysis medical societies patient compliance patient satisfaction phenols phenols (class of compounds).
Alfentanil is a synthetic short-acting opioid with analgesic and local anesthesia enhancing activity. Alfentanil primarily binds to mu-opioid receptor, a g-protein-coupled receptor, thereby mimicking the actions of morphine, the prototypical mu receptor agonist.
Alfentanil 5 mg/ml solution for injection is a potent opioid analgesic with a very rapid onset of action. It is indicated for analgesia and suppression of respiratory activity in mechanically ventilated patients on intensive care and to provide analgesic cover for painful manoeuvres.
Alfentanil, a rapid and short-acting synthetic analog of fentanyl, appears to offer clinically significant advantages over fentanyl during outpatient anesthesia. It is reasonable to hypothesize that low dose of alfentanil used in bps might also result in more rapid recovery as compared with fentanyl.
Alfentanil is a short-acting opioid, used in anesthesia with a target controlled infusion (tci). Pharmacokinetic model used derived from normal weight patients. Proposition of another model to compare the obtained results. Administration of alfentanil to ten obese patients undergoing.
As a fentanyl analogue, alfentanil hydrochloride mainly acts on μ-opioid receptor, is a short-acting potent analgesic used for anesthesia and applies to short surgical procedures.
19292) is an analytical reference standard characterized as an opioid. 1 alfentanil is regulated as a schedule ii compound in the united states. This product is intended for research and forensic applications.
Alfentanil: synthetic mu-opioid receptor agonist analgesic drug. Analogue of the synthetic opioid fentanyl that is only 10% as potent (on a weight-to-weight basis), but has quicker onset, quicker time to maximal effect, shorter duration of action (10 minutes), is more cardiovascularly stable and has more respiratory depression.
Compatibility/stability of alfentanil with other support-ive drugs in 8 commonly encountered drug combina-tions, at minimum and maximum concentrations. A cme t34 syringe pump was used to simulate infusion of the syringe preparation over a 24 hr period. A total of 16 combinations were analysed by high performance liquid chromatography-diode.
The performance of maitre and colleagues' model was particularly bad at the first sample, 1 min after the start of alfentanil infusion (the only one sample realized before effect-site and plasma target concentration equilibration), and some hypothesis may explain this situation.
Nov 3, 2020 alfentanil: synthetic mu-opioid receptor agonist analgesic drug. And for improving the clinical performance of individuals and collectives.
Background there is increasing interest in balanced propofol sedation (bps) titrated to moderate sedation (conscious sedation) for endoscopic procedures. However, few controlled studies on bps targeted to deep sedation for diagnostic endoscopy were found. Alfentanil, a rapid and short-acting synthetic analog of fentanyl, appears to offer clinically significant advantages over fentanyl during.
1: alfentanil alfenta® high performance liquid chromatography/ tandem mass spectrometry (lc-ms/ms) ng/ml: 2: anesthetic, opioid analgesic: 2: noralfentanil.
Alfentanil and the elimination of sympathetic responses to tracheal intubation during rapid sequence induction of anesthesia: a probability-based approach.
alfentanil is synthetic opioid phenylpiperidine series-tetrazole derivative of fentanyl introduced in 1980. less potent (1/5th to 1/10th) and has 1/3rd the duration of action of fentanyl.
This product information is intended only for residents of the united states.
Alfentanil yield grams alcohol sufentanil prior art date 1999-12-06 legal status (the legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed. ) expired - fee related application number us11/362,498 other versions us20060149071a1.
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Analysis of national practice (1) identified 8 commonly used drug combinations administered by csci that included alfentanil. Aim(s) and method(s) to determine the chemical compatibility/stability of alfentanil with other supportive drugs in 8 commonly encountered drug combinations, at minimum and maximum concentrations.
Alfentanil hydrochloride injection is a potent analgesic used for anesthesia and applies to short surgical procedures. As a fentanyl analogue, alfentanil hydrochloride mainly acts on μ-opioid receptor, is a short-acting potent analgesic used for anesthesia and applies to short surgical procedures.
The temazepam drug is one type of medication used by patients with sleep disorders or insomnia. This drug has a performance in sleep cycle so that it can start a good and long night's sleep. Here are the temazepam 15 mg benefits, how to use, and side effects.
Amélie marsot1 duration of alfentanil infusion (min) data analysis included calculation of performance error (pe).
The performance of the fitting was assessed by the coefficient of correlation between predicted and observed effect. Alfentanil induced a high‐amplitude low‐frequency eeg response. At low concentrations, both frequency and amplitude increased.
Alfentanil has the fastest onset of action, followed by sufentanil and then fentanyl. Alfentanil also has the shortest duration of action of the group. Most studies of these agents have been done to assess their role as anesthetics in cardiac surgery.
Determination of fentanyl and alfentanil in plasma by high-performance liquid chromatography with ultraviolet detection.
Alfentanil interacts predominately with the opioid mu-receptor. These mu-binding sites are psychomotor performance after short-term anaesthesia.
All patients had continuous pulse oximetry monitoring and hourly recording of pain, sedation, nausea scores and respiratory rate. Patients receiving alfentanil had the target concentration noted hourly and four blood samples taken during the first 24 h for measurement of plasma alfentanil concentrations by high performance liquid chromatography.
Alfentanil (r-39209, trade name alfenta, rapifen in australia) is a potent but short-acting synthetic opioid analgesic drug, used for anaesthesia in surgery. It is an analogue of fentanyl with around one-fourth to one-tenth the potency, one-third the duration of action, and an onset of action four times faster than that of fentanyl.
In humans, alfentanil at therapeutic doses had no detrimental effects on myocardial performance. The cardiovascular stability is remarkable both in healthy and poor-risk patients. The only changes seen in blood pressure and heart rate are transient, slight decreases occurring immediately after induction.
The alfentanil infusion system was equally effective as an analgesic technique when compared with morphine.
Results: plasma alfentanil concentrations during computer-controlled infusion pump administration exceeded target concentrations for the first 10 min of drug administration, and from 300 min to the end of the study.
Sd) requiring mechanical ventilation and prolonged sedation/analgesia after major surgery or trauma. Interventions plasma propofol and alfentanil concentrations were measured at regular intervals during the long-term drug infusion using a high-performance liquid chromatography (propofol) and radioimmunoassay (alfentanil) analysis.
Whole-body pbpk model of alfentanil as cyp3a4 ddi victim drug report using the snapshot and static text blocks to display the performance of the model.
The performance and accuracy of the models devised by maitre and colleagues and scott and colleagues were evaluated in a population including morbidly obese patients.
Driving at the start of therapy with opioid analgesics, and following.
Performance of aep monitor/2-derived composite index as an indicator for depth of sedation with midazolam and alfentanil during gastrointestinal endoscopy.
0 nm 11 t0 2 name retention time area resolution (dab) conclusion to determine the chemical compatibility/stability of alfentanil with other supportive drugs in 8 drug combinations, at minimum and maximum concentrations.
Nov 6, 2014 adding propofol to alfentanil increases sedation, potentiates is widely used for sedation during the performance of different procedures.
Includes: how it works, upsides, downsides, bottom line, tips, response and effectiveness.
First part looked at the effects of alfentanil on the induction induction dose of alfentanil (10 l1g1kg).
(grup r) 1 mg midazolam + has a potent sedative efficiency when combined with narcotic analgesics.
Key words: midazolam, fentanyl, alfentanil, follicular fluid, transvaginal oocyte retrieval centrations were obtained before performance of the paracervical block.
Pharmacokinetic parameter sets of alfentanil revisited: optimal parameters for use in target controlled infusion and anaesthesia display systems march 2013 bja british journal of anaesthesia 111(2).
Opioids, such as alfentanil, buprenorphine, or codeine; pimozide; st john's wort; tacrolimus. Note that this list is not all-inclusive and includes only common medications that may interact with nifedipine. You should refer to the prescribing information for nifedipine for a complete list of interactions.
The controller adjusted the alfentanil infusion rate to maintain the mean arterial blood pressure near the set-point (70 mmhg) while minimizing the cp alf toward the set-point plasma alfentanil concentration (cp alfref) (100 ng/ml). Results: two patients were excluded because of loss of arterial pressure signal and protocol violation.
Also, sedation techniques that support advanced, high-quality, in-patient care procedures representing easy performance and rapid recovery are requested for increased effectiveness. In this doctoral thesis, patient-controlled sedation (pcs) using propofol and alfentanil for surgical and diagnostic procedures was studied.
Alfentanil causes less postoperative nausea and vomiting than equipotent doses of fentanyl or sufentanil in outpatients.
Alfentanil is a potent synthetic mu-opioid receptor agonist analgesic drug it is a analogue of the synthetic opioid fentanyl that is only 10% as potent (on a weight-to-weight basis), but has quicker onset, quicker time to maximal effect, shorter duration of action (10 minutes), is more cardiovascularly stable and has more respiratory depression.
Fentanil, alfentanil and sufentanil are among the most potent agents being preferentially used transoperatively.
The temazepam drug is one type of medication used by patients with sleep disorders or insomnia. This drug has a performance in sleep cycle so that it can start a good and long night’s sleep. In addition, this remedy can also keep your sleep cycle so as not to awaken in the middle of the night.
An extra bolus of analgesi c was given to six of 14 patients in the alfentanil group and eight of 15 in the fentanyl group. The plasma concentration of alfentanil was stable from the first measurement (10 min) at approximately 350 ng ml1, while the plasma.
The performance of a patient-demand, target-controlled alfentanil infusion system was compared with that of a traditional morphine patient-controlled analgesia (pca) pump in 120 adult patients after cardiac surgery.
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