Document Type: Article All Authors / Contributors: M Chi; Y Zhou; D Sopariwala; M Periasamy ISSN:0916-8737 BL Shelfmark:5064.711500 Language Note: English Unique Identifier: 777424189 Awards:
| Title | : | SM2 /- male mice are predisposed to develop urinary tract obstruction and hyper contractility of the bladder smooth muscle upon ageing |
| Author | : | M Chi; Y Zhou; D Sopariwala; M Periasamy |
| Language | : | en |
| Rating | : | 4.90 out of 5 stars |
| Type | : | PDF, ePub, Kindle |
| Uploaded | : | Apr 12, 2021 |
Full Download SM2 /- male mice are predisposed to develop urinary tract obstruction and hyper contractility of the bladder smooth muscle upon ageing - M Chi; Y Zhou; D Sopariwala; M Periasamy file in ePub
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Some characteristics include low susceptibility to developing atherosclerotic aortic lesions, high-frequency hearing loss, susceptibility to audiogenic seizures, development of progressive eye abnormalities that closely mimic human hereditary glaucoma, and extreme intolerance to alcohol and morphine.
The sm2 homozygous knockout (sm2(-/-)) mice died within 30 days after birth, showing pathologies including segmental distention of alimentary tract, retention of urine in renal pelvis, distension of bladder, and the development of end-stage hydronephrosis. In contrast, the heterozygous (sm2(+/-)) mice appeared normal and reproduced well.
Inflammatory bowel disease (ibd) is a complex multifactorial disease of unknown etiology. Thus, dozens of different animal models of ibd have been developed in past decades. Animal models of ibd are valuable and indispensable tools that provide a wide range of options for investigating involvement of various factors into the pathogenesis of ibd and to evaluate different therapeutic options.
A population of gr‐1 high ly‐6g+cd11b+ myeloid cells was found to be constitutively increased in male (nzb × nzw)f1 mice as compared with female mice and was regulated by testosterone. The cells were located adjacent to spleen b cell follicles in vivo and were found to directly inhibit cytokine‐induced differentiation of naive b cells.
Mice that have been barbered extensively can have large bald patches on their bodies, commonly around the head, snout, and shoulders, although barbering may appear anywhere on the body. Barbering is more frequently seen in female mice; male mice are more likely to display dominance through fighting.
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Thus, m3r is critical for voiding in male mice, and males lacking m3r expres- sm2 (sm2 +/-mice) exhibit a bladder phenotype that is strikingly similar to that of mras-/-mice.
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Sm2(+/−) male mice are predisposed to develop urinary tract obstruction and hyper contractility of the bladder smooth muscle upon ageing.
Sm2(+/−) male mice are predisposed to develop urinary tract obstruction and hyper contractility of the bladder smooth muscle upon ageing in this study we generated a mouse model specifically.
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Background in humans the prevalence of asthma is higher among females than among males after puberty. Objective we tested the hypothesis that female mice are more susceptible to the development of allergic asthma than male mice and studied allergic immune responses in the lung.
It is difficult to house male mice together without the risk of injury to one or both males. Some people, however, prefer the personality and curiosity of male mice. It is a good idea to keep fancy mice in groups of at least two if possible, as mice are sociable animals.
Sm2(+/-) male mice are predisposed to develop urinary tract obstruction and hyper contractility of the bladder smooth muscle upon ageing. J smooth muscle res, 47(3-4):67-78, 01 jan 2011 cited by: 4 articles pmid: 21979406.
These mutant male mice with the knockout alleles exhibited normal behavior in everyday activities such as eating and exploration, but when prompted, attacked intruders with twice the intensity of normal male mice.
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