Document Type: Article All Authors / Contributors: Chan M.M.; Adapala N.; Chen C. ISSN:1687-4757 Language Note: English Unique Identifier: 781753589 Awards:
| Title | : | Peroxisome proliferator-activated receptor-γ-mediated polarization of macrophages in leishmania infection |
| Author | : | Chan M.M.; Adapala N.; Chen C. |
| Language | : | en |
| Rating | : | 4.90 out of 5 stars |
| Type | : | PDF, ePub, Kindle |
| Uploaded | : | Apr 12, 2021 |
Full Download Peroxisome proliferator-activated receptor-γ-mediated polarization of macrophages in leishmania infection - Chan M.M.; Adapala N.; Chen C. file in ePub
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Peroxisome proliferator-activated receptor (ppar)-γ is a nuclear hormone receptor that comprises an agonist-dependent activation domain (af-2), dna binding domain, and agonist-independent activation domain (af-1). It is expressed predominantly in adipose tissue but is expressed in other tissues as well upon the binding of the agonists, ppar.
Peroxisome proliferator-activated receptors (ppars) are transcription factors belonging to the nuclear receptor gene superfamily (mangelsdorf and evans, 1995).
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (pgc-1α) is a protein that in humans is encoded by the ppargc1a gene. Ppargc1a is also known as human accelerated region 20 (har20). It may, therefore, have played a key role in differentiating humans from apes.
Peroxisome proliferator-activated receptors (ppars), originally cloned in an attempt to identify the molecular mediators of peroxisome proliferation in the liver of rodents, 1 are ligand-activated transcription factors belonging to the nuclear receptor superfamily, which also includes the steroid and thyroid hormone receptors.
Expression of the peroxisome proliferator-activated receptor gamma (ppargamma) in human atherosclerosis and regulation in macrophages by colony stimulating factors and oxidized low density lipoprotein.
Peroxisome proliferator-activated receptor γ (pparγ) is a ligand-activated transcription factor belonging to the nuclear hormone receptor superfamily.
The nuclear receptor known as peroxisome proliferator–activated receptor α (pparα) was found to play a role in regulating mitochondrial and peroxisomal fatty acid oxidation, suggesting that pparα may be involved in the transcriptional response to fasting.
Peroxisome proliferator-activated receptors (ppars), including ppar-α, ppar-δ, and ppar-γ, are a family of ligand-activated nuclear receptors that function as transcription factors to regulate gene expressions closely related to lipogenesis, lipid metabolism, and foam cell formation in macrophages.
Recent studies have implicated peroxisome proliferator-activated receptor alpha (pparα) as a potential target to modulate regulation of the immune response.
Peroxisome proliferator-activated receptors (ppar) are members of the nuclear hormone receptor superfamily of ligand-activated.
Peroxisome proliferator activated receptors (ppars) are members of the nuclear receptor super family that modulate gene expression upon ligand activation.
Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to dna specific ppar response elements (ppre) and modulates the transcription of its target genes, such as acyl-coa oxidase.
Peroxisome proliferator-activated receptor beta or delta (ppar-β or ppar-δ), also known as nr1c2 (nuclear receptor subfamily 1, group c, member 2) is a nuclear receptor that in humans is encoded by the ppard gene. This gene encodes a member of the peroxisome proliferator-activated receptor family.
Peroxisome proliferator-activated receptors are ligand-activated transcription factors that regulate genes important in cell differentiation and various metabolic processes, especially lipid and glucose homeostasis.
Peroxisome proliferator-activated receptor gamma (ppar-γ or pparg), also known as the glitazone receptor, or nr1c3 (nuclear receptor subfamily 1, group c, member 3) is a type ii nuclear receptor (protein regulating genes) that in humans is encoded by the pparg gene.
Peroxisome proliferator-activated receptors (ppars) are a group of nuclear regulatory factors that provide fine tuning for key elements of glucose and fat metabolism and regulate inflammatory cell activation and fibrotic processes.
Peroxisome proliferator-activated receptor beta/delta agonist suppresses inflammation and promotes neovascularization.
Peroxisome proliferator-activated receptors (ppars) are involved in the regulation of inflammatory reactions and lipid metabolism. The anti-inflammatory properties of ppars are mainly achieved by inhibiting nuclear factor-kappa b (nf- κ b) which, in turn, is the proinflammatory nuclear transcription factor.
Peroxisome proliferator–activated receptors (ppars) constitute a subfamily of the nuclear receptor super family (29). Three distinct ppars, termed α, δ, and γ, each encoded by separated genes and showing a distinct tissue distribution pattern, have already been described.
Positive regulation of the peroxisomal β-oxidation pathway by fatty acids through activation of peroxisome proliferator-activated receptors ( ppar.
Hscs activation, inflammation, oxidative stress, steatosis and aging play critical roles in the progression of liver fibrosis, which is correlated with the regulation of the peroxisome proliferator-activated receptor (ppar) pathway.
To date, only weight loss fully reverses nash pathology, but mixed peroxisome proliferator–activated receptor‐alpha/delta (ppar‐α/δ) agonists show some efficacy. Seladelpar (mbx‐8025), a selective ppar‐δ agonist, improves atherogenic dyslipidemia.
Nov 16, 2017 rxra regulates transcription as part of a heterodimer with 14 other nuclear receptors, including the peroxisome proliferator-activated receptors.
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (pgc-1α) is a protein that in humans is encoded by the ppargc1a gene. Ppargc1a is also known as human accelerated region 20 it may, therefore, have played a key role in differentiating humans from apes.
Peroxisome proliferator-activated receptors (ppars) are transcription factors belonging to the superfamily of nuclear receptors. They act on dna response elements as heterodimers with the nuclear retinoic acid receptor. Their natural activating ligands are fatty acids and lipid-derived substrates.
Peroxisome proliferator-activated receptor (ppar) agonists - reference pathway.
Jun 15, 2020 one of the three subtypes of the peroxisome proliferator-activated receptor ( ppar) functioning as a transcription factor is the pparβ or pparδ.
In the field of molecular biology, the peroxisome proliferator-activated receptors (ppars) are a group of nuclear receptor proteins that function as transcription factors regulating the expression of genes.
Fatty acids and peroxisome proliferators are among the compounds known to activate pparα (27–29), which binds its cognate elements as a heterodimeric.
Peroxisome proliferator-activated receptor γ (pparγ) is a nuclear hormone receptor that plays a key role in the differentiation of adipocytes. Activation of this receptor in liposarcomas and breast and colon cancer cells also induces cell growth inhibition and differentiation.
Peroxisome proliferator-activated receptor-γ (ppar-γ), a member of the ppar nuclear receptor family, is a ligand-activated transcription factor that regulates diverse biological activities and plays major roles in important human diseases such as diabetes mellitus, metabolic syndrome, and atherosclerosis.
Peroxisome proliferator–activated receptors (ppars) play key roles in the regulation of energy homeostasis and inflammation, and agonists of pparα and -γ are currently used therapeutically. Fibrates, first used in the 1970s for their lipid-modifying properties, were later shown to activate pparα. These agents lower plasma triglycerides and vldl particles and increase hdl cholesterol.
Peroxisome proliferator-activated receptors (ppars) peroxisome proliferator-activated receptor (ppar) is a subfamily of nuclear hormone receptors [6–8], that function as ligand-activated transcription factors to regulate various biological processes.
Peroxisome proliferator-activated receptor gamma (pparγ) is a nuclear receptor demonstrated to play an important role in various biological processes.
May 5, 2020 although oxidative stress alone will activate nrf2, you can enhance the effect if you use certain compounds.
Peroxisome proliferator activated receptors (ppars) are ligand-activated transcription factors, which regulate the expression of genes involved in lipid and glucose metabolism and that are associated with various cardiovascular risk factors [52–55].
Role of peroxisome proliferator‐activated receptors (ppars) in the pathophysiology of stroke and protective effects of ppar ligands have been widely investigated in the last 20 years. Activation of all three ppar isoforms, but especially ppar‐γ, was documented to limit postischemic injury in the numerous in vivo, as well as in in vitro.
Peroxisome proliferator-activated receptor beta/delta (pparbeta/delta) is a ligand-binding inducible transcriptional factor linked to carcinogenesis. Important functions of pparbeta/delta were demonstrated in series of human epithelial cancers; however, its role in lung cancer remains controversial.
Peroxisome proliferator-activated receptors (ppars) are nuclear receptors that regulate many functions that are disturbed in nafld, including glucose and lipid metabolism, as well as inflammation.
Peroxisome proliferator–activated receptors (ppars) constitute a subfamily of the nuclear receptor super family three distinct ppars, termed α, δ, and γ, each encoded by separated genes and showing a distinct tissue distribution pattern, have already been described.
Here is where peroxisome proliferator-activated receptor gamma (pparγ) activation comes as a viable option. Pparγ is a nuclear receptor that interacts with retinoid x receptor (rxr) and other cofactors to regulate transcription of target genes, thus regulating adipogenesis, metabolism, cellular differentiation and development, inflammation.
The peroxisome proliferator-activated receptor alpha (pparα) is a ligand-activated transcription factor involved in the regulation of a variety of processes, ranging from inflammation and immunity to nutrient metabolism and energy homeostasis.
The three peroxisome proliferator-activated receptors (ppars) are ligand-activated transcription factors of the nuclear hormone receptor superfamily. They share a high degree of structural homology with all members of the superfamily, particularly in the dna-binding domain and ligand- and cofactor-binding domain. Many cellular and systemic roles have been attributed to these receptors.
Peroxisome proliferator-activated receptor-alpha agonist treatment in a transgenic model of type 2 diabetes reverses the lipotoxic state and improves glucose homeostasis.
The peroxisome proliferator-activated receptor (ppar) family of nuclear receptors is composed of three family members: pparα, pparβ/δ (most commonly identified as pparδ), and pparγ. This transcription factor family was first identified in studies examining the cholesterol-lowering effects of fibrates.
Peroxisome proliferator-activated receptor γ (pparγ) belongs to the nuclear hormone receptor family and is a ligand-modulated transcriptional factor. Pioglitazone, a pparγ ligand of the thiazolidinedione class, exerts several pleiotropic effects including neuroprotection in addition to reducing blood glucose and insulin resistance; however, its mechanism remains obscure.
The peroxisome proliferator-activated receptors, pparα, pparβ, and pparγ, are a family of transcription factors activated by a diversity of molecules including.
Peroxisome proliferator-activated receptor γ (pparγ) is a member of the nuclear receptor superfamily of transcription factors that can be activated by lipophilic ligands. It plays important roles in the regulation of a diverse array of physiological processes, including adipogenesis, lipid metabolism, insulin sensitivity, and inflammation [1,2].
The peroxisome proliferator-activated receptors (pparalpha, gamma, delta) are members of the nuclear receptor superfamily of ligand-activated transcription factors that have central roles in the storage and catabolism of fatty acids.
Most, if not all, of the diverse effects of pps are mediated by three members of the nuclear receptor superfamily called peroxisome proliferator-activated receptors.
Dec 7, 2017 activation mediated by peroxisome proliferator-activated receptor (ppar) ligands and brown algae-based compounds: different mechanisms.
May 22, 2017 peroxisome proliferator-activated receptor gamma is a master regulator of adipogenesis in mammals, and mutations deleterious to pparg.
Peroxisome proliferator-activated receptors (ppars) are ligand-activated transcription factors involved in the regulation of different aspects of lipid metabolism, energy production, and inflammation. The role of ppars in the healthy and diseased heart has been a subject of intense research in the past years.
While searching for natural ligands for the peroxisome proliferator-activated receptor (ppar) γ, we identified a synthetic compound that binds to this receptor.
Peroxisome proliferator-activated receptors (ppars) are nuclear receptors acting as lipid sensors. Besides its metabolic activity in peripheral organs, the ppar beta/delta isotype is highly expressed in the brain and its deletion in mice induces a brain developmental defect.
Peroxisome proliferator-activated receptor γ (pparγ) and pparγ coactivator 1α ( pgc1α) play central roles in coordinating and driving energy metabolism, fatty.
Peroxisome proliferator-activated receptors are expressed in many tissues, including adipocytes, hepatocytes, muscles and endothelial cells; however, the affinity depends on the isoform of ppar, and different distribution and expression profiles, which ultimately lead to different clinical outcomes.
Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes.
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