Full Download Intracytoplasmic crystalline and globular inclusions in small lymphocytic lymphoma in transformation. - D Tasso Affiliation: Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA.; HE Gulbahce; MJ Berger; RW McKenna; SE Pambuccian file in ePub
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Nature of intracytoplasmic crystalline inclusions in myeloma cells (morphologic, cytochemical, ultrastructural, and immunofluorescent studies). The authors describe a 70-year-old woman with multiple myeloma and adult fanconi syndrome.
A macrophage (mac) adjacent to a lymphocyte (lym) contains crystalline intracytoplasmic immunoglobulln, some of which has a hexagonal configuration (asterisk). (uranyl acetate and lead citrate stain; magnification x 7,992. ) (inset) a macrophage (mac) and fibrocyte (fib) contain intracyfoplasmic crystalline structures.
Immunofluorescent studies showed strong iga and kappa activity in the cytoplasm of the tumor cells, but the fluorescence was absent in the region of the crystals, which were identified easily by their negative birefringence. The authors interpret these observations to indicate that the intracytoplasmic crystals in this case are of lysosomal origin.
Inclusion bodies are aggregates of specific types of protein found in neurons, a number of tissue cells including red blood cells, bacteria, viruses, and plants. Inclusion bodies of aggregations of multiple proteins are also found in muscle cells affected by inclusion body myositis and hereditary inclusion body myopathy.
This case report describes intracytoplasmic crystalline inclusions in the hepatocytes of a 13-year-old female thomson's gazelle. Histologically, multifocal to coalescing areas of many hepatocytes contained large cytoplasmic vacuoles filled with pale eosinophilic homogeneous material and rare fine basophilic granules.
Crystal-storing histiocytosis (csh) is a rare disorder characterized by the accumulation of nonneoplastic histiocytes containing intracytoplasmic crystallized immunoglobulins. In most cases, there is an associated underlying lymphoplasmacytic neoplasm expressing ig kappa light chain.
Icsi is an acronym for intracytoplasmic sperm injection; a fancy way of saying “inject sperm into egg” icsi is a very effective method to fertilize eggs in the ivf lab after they have been aspirated from the female.
Hemoglobin h crystals are associated with hemoglobin h disease. These cells are stained with brilliant cresyl blue stain which stain hemoglobin h bodies composed of beta globin chains in tetrads. An impaired formation of alpha-chains leads to an overage of beta-chains.
Unusual intracytoplasmic crystalline inclusions in chronic myelomonocytic leukemia with double minute chromosomes and myc amplification: a rare case.
Keratin (/ ˈ k ɛr ə t ɪ n /) is one of a family of fibrous structural proteins known as scleroproteins. It is the key structural material making up scales, hair, nails, feathers, horns, claws, hooves, calluses, and the outer layer of skin among vertebrates.
Histologically, the lesion showed mature plasmacytes, plasmacytoid cells, and large mononuclear cells that exhibited myriad intracytoplasmic crystals. Electron microscopic studies disclosed that the large mononuclear cells, which showed plas.
Many plasma cells showed multiple, pink, auer rod-like crystalline intracytoplasmic inclusions.
(d) on high power inspection, the intracytoplasmic inclusions have a fibrillar in lcfs, the crystalline deposits are intracellular and confined to proximal tubules.
Some authors have noted that intracytoplasmic crystals may also be seen in reactive plasma cell infiltrates,19but this seems to be a very rare event and few such cases have been documented in detail. 710to our knowledge, crystalline inclusions have been described only once previously in a patient with gastritis,11 and in that case the plasma cells.
The presence of intracytoplasmic crystalline inclusions in b‐cell lymphoproliferative disorders (most frequently cll) is uncommon. 1, 2 these inclusions, which may appear rectangular or globular by light microscopy, localize within rough endoplasmic reticulum by electron microscopy and typically consist of the immunoglobulin heavy and light chains detected on the cell surface (most commonly igm lambda).
The protostyle or crystalline style may vary in form among the bivalves. Digestion in primitive forms appears to have been both intracellular.
All (75%, block staining), alpha-1-antitrypsin inclusions, alveolar soft part sarcoma (intracytoplasmic crystals), aml-m5a, m6 (60%), m7, basement membrane containing tumors (cylindroma), clear cell tumors, malakoplakia, renal cell carcinoma (pas+ glycogen removed with diastase), parasites.
Mar 14, 2006 variable numbers of plasma cells with intracytoplasmic crystalline inclusions in the superficial lamina propria were seen.
Feb 1, 2016 there is evidence of intratubular and intracellular crystalline inclusions or sometimes non-crystalline accumulations of light chain.
The first demonstration of the direct piezoelectric effect was in 1880 by the brothers pierre curie and jacques curie. They combined their knowledge of pyroelectricity with their understanding of the underlying crystal structures that gave rise to pyroelectricity to predict crystal behavior, and demonstrated the effect using crystals of tourmaline, quartz, topaz, cane sugar, and rochelle salt.
Crystalline retinopathy is a term that encompasses a wide spectrum of clinical conditions characterized by refractile.
Intracytoplasmic crystalline inclusions occurring in circulating lymphocytes in chronic lymphocytic leukemia and in the neoplastic cells of plasma-cell tumors have been the subject of several case.
Dec 2, 2019 intracellular immunoglobulin light chain aggregation is shown to be associated with biochemical properties of individual light chain clones.
In fact, most polymers are semicrystalline, which means that they contain a mixture of crystalline.
Download scientific diagram plasma cell myeloma with intracytoplasmic and extracellular rhomboid crystalline inclusions.
Aug 11, 2017 cytoplasmic crystalline inclusion bodies in plasma cells have been repeatedly reported, mainly concentrated in the auer rod-like inclusions.
Icsi is a male infertility treatment utilized in ivf procedures. For male infertility testing and treatments, visit the atlanta center for reproductive medicine.
Intracytoplasmic crystalline material that stained for monotypic light chain can be seen in the proximal tubules figure 2: trichrome intracytoplasmic crystals. Figure 3: kappa-light chain restricted atypical plasma cell infiltrate (in situ hybridization).
Studies on intracytoplasmic crystalline inclusion bodies in parietal cells of fattened steers.
Renal biopsy showed substantial acute tubular injury with unusual cytoplasmic changes.
Jan 6, 2012 figure 3: a trinucleate plasma cell showing intracytoplasmic crystalline inclusions (geimsa stain, ×1000) click here to view.
Crystals: crystalline inclusions have long been recognized as normal constituents of certain cell types such as sertoli cells and leydig cells of the human testis, and occasionally in macrophages. It is believed that these structures are crystalline forms of certain proteins which is located everywhere in the cell such as in nucleus.
Results: intracellular crystals were not observed in the cells from choroideremia- affected males.
Jul 5, 2016 lcpt has a distinct light microscopy and ultrastructural appearance and occurs due to intracytoplasmic deposition of monoclonal kappa light.
Jan 29, 2018 some variants of intracytoplasmic crystals have also been reported, including clofazimine crystals in clofazimine-induced csh among.
Jun 24, 2011 light chain proximal tubulopathy without crystal deposition is only no evidence of intracytoplasmic crystals and three with intracytoplasmic.
4,13 the presence of crystalline casts is regarded as t d accepted manuscript uncommon in lcpt and their presence is typically only a focal finding.
Alveolar soft part sarcoma: pas+ intracytoplasmic crystalline rods and granules; no pleomorphism, no giant cells, no fibrous septa, negative for muscle specific actin and myoglobin embryonal rhabdomyosarcoma (erms): in contrast to solid variant arms, dense erms is characterized by variation in cellular and nuclear size and shape within a tumor.
While lcpt is usually associated with intracytoplasmic deposition of crystallized light chains, the intraluminal light chain casts in lccn are typically amorphous and do not form crystals.
This is an open access article distributed under the creative commons attribution license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. This case report describes intracytoplasmic crystalline inclusions in the hepatocytes of a 13-year-old female thomson’s gazelle.
Intracytoplasmic crystalline inclusions in the hepatocytes of humans and chimpanzees.
Crystals and crystalloids of intracytoplasmic filaments crystalline filamentous cylinders asteroid bodies references 12 microtubules introduction structure, function and variations references 13 cytoplasmic matrix and its inclusions introduction the dark cell-light cell phenomenon dark and light cells in tumors glycogen.
Light chain proximal tubulopathy (lcpt) is characterized by cytoplasmic inclusions of monoclonal lc within proximal tubular cells.
Intracytoplasmic crystalline and globular inclusions in small lymphocytic lymphoma in transformation.
Jul 7, 2016 intracellular crystalline inclusions within proximal tubular epithelial cells. Similar crystals in bone marrow plasma cells not all cases with fanconi.
Here, we present a case of plasma cell myeloma with intracellular crystalline eosinophilic inclusions and extracellular crystal depositions in the bone marrow.
) (b) a higher-magnification view reveals regular periodic parallel lines with about 5-nm intervals. The crystals were rectangular and rhomboidal in shape and ranged from 2 to 10 μm in long axis.
Inclusions, the intracytoplasmic crystalline inclusions have been reported in only a few oligodendrogliomas [2^7] and glioblastoma multiforme [8], in which the,majorities were single membrane-bound form mixed withsomenon-membrane-boundcrystals. Intranuclear crystals were also described in an oligodendroglioma [15].
Plasma cells from an igd myeloma contained intracytoplasmic crystals. By electron microscopy, these crystals had 13-nm periodicity and were contained within vacuoles formed of smooth membranes.
Intracytoplasmic crystalline inclusions (ccis) were observed in liver biopsy specimens taken from three patients and three chimpanzees. Ccis are rare in human hepatocytes and have never been described in chimpanzees. All three human cases were connected with alcoholic liver disease; no viral infection was noted.
Nov 14, 2019 immunofixation electrophoresis detected monoclonal iga-kappa (κ) paraprotein in both serum and urine.
The accumulation of intracytoplasmic crystalline inclusions is a rare but well-described feature of b cell lymphoproliferative disorders and is seen most commonly in lymphomas showing plasmacytic differentiation. 1 the formation of crystals in such cases is thought to reflect the altered production, storage or secretion of ig products by the neoplastic cells, and it seems likely that the abnormal proteins exhibit an increased physicochemical tendency to crystallisation.
This case report describes intracytoplasmic crystalline inclusions in the hepatocytes of a 13-year-old female thomson's gazelle. Histologically, multifocal to coalescing areas of many hepatocytes.
The intracytoplasmic crystal-like inclusions showed weak immunoreactivity for igg and κ and λ light-chain immunoglobulins (fig.
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