Full Download The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescence. - JI Alvarez Affiliation: Neuroimmunology Unit, Center of Excellence in Neuromics, Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Faculty of Medicine, Université de Montréal, Montréal, Quebec, Canada.; A Dodelet-Devillers; H Kebir; I Ifergan; PJ Fabre; All authors | PDF Online

Read Online The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescence. - JI Alvarez Affiliation: Neuroimmunology Unit, Center of Excellence in Neuromics, Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Faculty of Medicine, Université de Montréal, Montréal, Quebec, Canada.; A Dodelet-Devillers; H Kebir; I Ifergan; PJ Fabre; All authors file in PDF

Document Type: Article All Authors / Contributors: JI Alvarez Affiliation: Neuroimmunology Unit, Center of Excellence in Neuromics, Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Faculty of Medicine, Université de Montréal, Montréal, Quebec, Canada.; A Dodelet-Devillers; H Kebir; I Ifergan; PJ Fabre; S Terouz; M Sabbagh; K Wosik; L Bourbonnière; M Bernard; van Horssen J; de Vries HE; F Charron; A Prat ISSN:0036-8075 Language Note: English Unique Identifier: 776486223 Awards: Abstract: The blood-brain barrier (BBB) is composed of tightly bound endothelial cells (ECs) and perivascular astrocytes that regulate central nervous system (CNS) homeostasis. We showed that astrocytes secrete Sonic hedgehog and that BBB ECs express Hedgehog (Hh) receptors, which together promote BBB formation and integrity during embryonic development and adulthood. Using pharmacological inhibition and genetic inactivation of the Hh signaling pathway in ECs, we also demonstrated a critical role of the Hh pathway in promoting the immune quiescence of BBB ECs by decreasing the expression of proinflammatory mediators and the adhesion and migration of leukocytes, in vivo and in vitro. Overall, the Hh pathway provides a barrier-promoting effect and an endogenous anti-inflammatory balance to CNS-directed immune attacks, as occurs in multiple sclerosis.

Title : The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescence.
Author : JI Alvarez Affiliation: Neuroimmunology Unit, Center of Excellence in Neuromics, Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Faculty of Medicine, Université de Montréal, Montréal, Quebec, Canada.; A Dodelet-Devillers; H Kebir; I Ifergan; PJ Fabre; All authors
Language : en
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Uploaded : Apr 12, 2021

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