Read Exogenous ether lipids predominantly target mitochondria. - L Kuerschner Affiliation: Life and Medical Sciences Institute, LIMES, University of Bonn, Bonn, Germany. lars.kuerschner@uni-bonn.de; D Richter; HK Hannibal-Bach; A Gaebler; A Shevchenko; All authors file in ePub
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Exogenous Ether Lipids Predominantly Target Mitochondria
Exogenous ether lipids predominantly target mitochondria.
(PDF) Exogenous Ether Lipids Predominantly Target Mitochondria
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Sedimentary membrane lipids recycled by deep-sea benthic archaea
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The occurance of ether lipids in animal tissues is well known. Cells of higher plants probably do not contain ether lipids (mangold 1972), but they incorporate exogenous alkylglycerols into neutral and ionic ether glycerolipids (kolattukudy and walton 1972; weber and mangold 1983; weber and benning 1983).
Plasmalogens as well as some 1-o-alkyl lipids are ubiquitous and sometimes major parts of the cell membranes in mammals and anaerobic bacteria. In archaea, ether lipids are the major polar lipids in the cell envelope and their abundance is one of the major characteristics that separate this group of prokaryotes from the bacteria.
Archaea reutilized exogenous lipids from relic cells and detritus to build their 35 endogenous membrane lipids. Our findings imply that at least some benthic archaea build their membranes by recycling sedimentary organic compounds in order to minimize the de novo lipid synthesis for growth and maintenance.
Although they are composed primarily of carbon and hydrogen, lipid molecules may also for example, lipids containing saturated fatty acids are solids at room.
Cannabinoids (/ k ə ˈ n æ b ə n ɔɪ d z ˌ ˈ k æ n ə b ə n ɔɪ d z /) are compounds found in cannabis. The most notable cannabinoid is the phytocannabinoid tetrahydrocannabinol (thc) (delta9-thc or delta8-thc), the primary psychoactive compound in cannabis.
Chylomicrons are assembled in the intestinal mucosa as a means to transport dietary cholesterol and triglycerides to the rest of the body. Chylomicrons are, therefore, the molecules formed to mobilize dietary (exogenous) lipids. The predominant lipids of chylomicrons are triglycerides (see table above).
Fatty acyl-coa reductase 1 (far1) is a ubiquitously expressed peroxisomal membrane protein that generates the fatty alcohols required for the biosynthesis of ether lipids. Lipid droplet localization of exogenously expressed and endogenous human far1 was observed by fluorescence microscopy under conditions of increased triglyceride synthesis in tissue culture cells.
Although characterized by slow growth rate, preventing prostate cancer progression to an aggressive stage is a major challenge. Focused on cancer metabolism and showed increased fatty acid uptake in human malignant prostate cancer tissue. The increased uptake was mediated by up-regulation of the fatty acid translocase cd36.
Because dhap-at and dhap-s catalyze the initial steps in ether lipid it was the intention of the present study to focus mainly on the putative “lipid role” of the incorporation and transmembrane movement of exogenous phospholipids.
Archaebacterial ether lipids: i ether bonds are more stable than ester bonds i they are twice the length of phospholipids and sphingolipids i they span the width of the surface membrane i at each end of the molecule two glycerol moieties are present i this glycerol is linked to either phosphate or sugar residues hliu.
A particle of the class lipoproteins responsible fro the transport of exogenous cholesterol and triglycerides from the small intestine to tissues after meals. A chylomicron is a spherical particle with a core of triglycerides surrounded by a monolayer of phospholipids, cholesterol, and apoliproteins.
Polyethylene glycol (peg; / ˌ p ɒ l i ˈ ɛ θ əl ˌ iː n ˈ ɡ l aɪ ˌ k ɒ l,-ˌ k ɔː l /) is a polyether compound derived from petroleum with many applications, from industrial manufacturing to medicine.
Nov 26, 2019 an aadacl1 ether lipid substrate is phosphorylated in platelets and acts as an decreased aggregation and secretion were rescued by exogenous therefore, hag or a metabolite mainly impacts adp secretion.
Lipid droplets are structurally similar to circulating lipoproteins in that they have a core of esterified lipids (tag, cholesterol ester, retinol esters, or ether lipids, depending on the cell type) that is encased by a phospholipid monolayer and a coat of specific proteins.
As with other ether lipids (see this web page for further discussion), the product is lpcat1 is expressed in the lungs mainly, where it produces paf and and possibly as endogenous paf-receptor antagonist/partial agonists.
Thus they require more strong and durable membrane lipids than prokaryotes and eukaryotes. Archaebacterial ether lipids consists of long (32c) branched hydrocarbon chains linked at both end to glycerol. The linkage of hydrocarbon chains to the glycerol is through ether bonds (r – o – r’) rather than the usual ester bonds.
We suggest that analyses and comparisons of predominantly of cl ([12, 30], resp.
Found in fats, glycerophospholipids, sphingolipids and serving as as membrane anchors for proteins and other biomolecules, fatty acids are important for energy storage, membrane structure, and as precursors of most classes of lipids.
Kuerschner l, richter d, hannibal-bach hk et al (2012) exogenous ether lipids predominantly target mitochondria. Plos one 7(2):e31342 crossref pubmed pubmedcentral google scholar lee sj, xu h, kang lw et al (2003) light adaptation through phosphoinositide-regulated translocation of drosophila visual arrestin.
Pether lipids are modified phospholipids containing an alkyl chain attached to the isn-1 /iposition by an ether linkage.
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The exogenous lipids are either incorporated unchanged or the pc resulting in the synthesis of a variety of glycolipis, phosphoglycolipids and ether lipids. Polar lipids of mycoplasma species are rather simple, comprising primaril.
Increases are plotted against the ratio of carbon assimilation to lipid production (r a/p) as an indicator for auto- or heterotrophic source organisms of the lipid. Archaeal ether lipid-derived hydrocarbons (circles) and bacterial fatty acids (diamonds) were produced in either the presence (red symbols) or the absence (white symbols) of methane.
A family of 3-methoxypoly(ethylene glycol)–vinyl ether–1,2-dioleylglycerol (mpeg-ve-dog) lipopolymer conjugates, designed on the basis of dft calculations to possess a wide range of proton affinities, was synthesized and tested for their hydrolysis kinetics in neutral and acidic buffers. Extruded ∼100 nm liposomes containing these constructs in ≥90 mol % 1,2-dioleoyl-sn-glycero-3.
Any of a heterogeneous group of fats and fatlike substances characterized by being water-insoluble and soluble in nonpolar solvents, such as alcohol, ether, chloroform and apolipoproteins. -contain nonpolar c-h bonds and yield fatty acids or complex alcohols after hydrolysis.
Structural data on archaebacterial lipids is presented with emphasis on the ether lipids of the methanogens. These ether lipids normally account for 80–95% of the membrane lipids with the remaining 5–20% of neutral squalenes and other isoprenoids. Genus-specific combinations of various lipid core structures found in methanogens include diether-tetraether, diether-hydroxydiether, or diether.
Exogenous ether lipids predominantly target mitochondria kuerschner, lars; richter, doris hannibal-bach, hans kristian.
One fifth of all glycerophospholipids in humans are ether lipids featuring an alkyl chain at the sn-1 position and commonly an ethanolamine or choline head-group. Highly abundant in certain tissues ether lipids are linked to pathologies and genetic disorders although their biological function remains unclear.
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Escherichia coli lipid genes graphical abstract highlights d knockout or overexpression of lipid-related genes leads to distinctive lipidomes d links between lipid classes and cell growth are established d lipidomic changes due to exogenous stress can be modeled d high-throughput lipidomics allows the analysis of 300 samples per day authors.
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