Download 1H n.m.r. studies of insulin. Assignment of resonances and properties of tyrosine residues. - Bradbury, J H; Ramesh, V | ePub
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1H n.m.r. studies of insulin. Assignment of resonances and
1H n.m.r. studies of insulin. Assignment of resonances and properties of tyrosine residues.
1H n.m.r. studies of insulin. Reversible transformation of 2
(PDF) 1H n.m.r. studies of insulin. Reversible transformation
Studies of the association and conformational properties of
2D 1H NMR studies of monomeric insulin. - Abstract - Europe PMC
Structure and dynamics of a protein assembly. 1H-NMR studies
FT-IR, Laser-Raman, UV-Vis, and NMR Spectroscopic Studies of
Two-dimensional NMR and photo-CIDNP studies of the insulin
13C NMR studies of insulin. Part I—Spectral assignments
Comparative 2D NMR studies of human insulin and des
Spectroscopic Studies of the Amino Groups of Insulin - FEBS Press
Paradoxical structure and function in a mutant human insulin - PNAS
Nuclear Magnetic Resonance Studies of Glucose Metabolism in
One-dimensional 1H-NMR studies of amide-proton exchange in
1H-NMR Assignment and Secondary Structure of Human Insulin
Insulin Warning Effects! - Warnings Side Effects and More
1H NMR Studies of insulin: Histidine residues, metal binding
High resolution 1H-NMR studies of Des-(B26-B30)-insulin
High resolution 1 H-NMR studies of Des-(B26–B30)-insulin
500-MHz 1 H NMR studies of insulin: Complete assignment of
1H NMR Metabolomics and Full-Length RNA-Seq Reveal Effects of
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Abstract: in order to establish the conditions required for the observation of monomeric insulin in solution, a series of proton nuclear magnetic resonance.
In methylated insulin the dimethyl proton resonances of glycine-al, phenylalanine-b1 vious 19f and i3c nmr studies of insulin derivatives, in which.
Resonances of the four tyrosine residues of bovine 2-zinc insulin is reported, based on double resonance techniques, use of hahn spin echo pulse sequences and examination of specific derivatives nitrated at tyrosines a14 and a19 as well as des-(b26-b30)-insulin.
In the present work we report the first 500-mhz1h nmr studies of insulin. At this frequency all four proton resonances from the two histidines of each equivalent monomer are resolved. The resonances are assigned to the c(2)- and c(4)-imidazole protons of b5 his and b10 his employing carr-purcell pulse sequences to detect singlets and to observe approximatet 2 relaxation times.
Sep 1, 1996 the present review summarizes nmr studies carried out in our laboratory. Niddm patients produce insulin from the β islets of their pancreas; they are, to obtain high-resolution images and 1h, 13c, or 31p nmr spectr.
The present nmr studies are conducted in the presence of an organic cosolvent (20% acetic acid), under which conditions both proteins are monomeric and stably folded. Complete sequential assignment of human insulin is obtained and leads to the following conclusions.
Site-directed mutagenesis is used in conjunction with 1h nuclear magnetic resonance (nmr) and circular dichroism (cd) spectroscopy in order to find an insulin.
The structure and dynamics of the r6 human insulin hexamer are investigated by two- and three-dimensional homonuclear 1h-nmr spectroscopy. The r6 hexamer, stabilized by zn2+ and phenol, provides a model of an allosteric protein assembly and is proposed to mimic aspects of receptor recognition.
Pancreatic bovine insulin was studied in an acidic solution by nuclear magnetic resonance spectroscopy.
Human insulin-like growth factor-i (igf-i) was studied by two- dimensional 1h-nmr spectroscopy.
In order to establish the conditions required for the observation of monomeric insulin in solution, a series of proton nuclear magnetic resonance studies of insulin in a variety of solvents was undertaken. Optimal spectra were recorded in trifluoroethanol- water mixtures in a 1:2 ratio.
Studies at 270 mhz were made of the transformation of 2 zn insulin hexamer to 4 zn hexamer produced by the addition of anions (thiocyanate ion). Four separate h2 histidine resonances were observed for the b5 and b10 histidines in 2 zn hexamer at ph 7 and 9 and four separate resonances also occurred in the 4 zn hexamer.
Nmr spectroscopy biopharmaceutical with varying excipient concentrations were studied using 1d and diffusion.
Recent studies indicate acylated anthocyanins have better stability and antioxidative activity compared to their nonacylated counterparts. This study compared the effects of nonacylated and acylated anthocyanins on hepatic gene expression and metabolic profile in diabetic rats, using full-length transcriptomics and 1h nmr metabolomics.
Known and consistent bioactivity between samples of insulin is essential to correctly estimate the dose. Insulin concentration is not the same thing as bioactivity, however, and methods to correctly determine both are required. Here we show that one dimensional nuclear magnetic resonance (1d nmr), in contrast to, for example, reverse phase high pressure liquid chromatography, can be used to determine both insulin concentration as well as confirm the structural integrity required.
Jun 30, 2009 diabetes is characterized by hyperglycemia due to dysfunction of insulin secretion or action.
Meglitinides (glitinides) are insulin secretagogues, and they stimulate insulin release from the experimental 1h nmr chemical shift spectra of nateglinide.
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