Document Type: Article All Authors / Contributors: Liu L.; Ding S.; Zhong L.; Zhang J.; Qu H.; Li S. ISSN:1008-7125 Language Note: Chinese Unique Identifier: 783275089 Awards:
| Title | : | Proteomics analysis of helicobacter pylori in gastric cancer and chronic gastritis |
| Author | : | Liu L.; Ding S.; Zhong L.; Zhang J.; Qu H.; All authors |
| Language | : | en |
| Rating | : | 4.90 out of 5 stars |
| Type | : | PDF, ePub, Kindle |
| Uploaded | : | Apr 12, 2021 |
Download Proteomics analysis of helicobacter pylori in gastric cancer and chronic gastritis - Liu L.; Ding S.; Zhong L.; Zhang J.; Qu H.; All authors | PDF
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CiteSeerX — • BRIEF REPORTS • Comparative proteome analysis
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Helicobacter pylori infection can lead to the development of gastric and duodenal ulcers and gastric cancer. In recent years, the efficacy of the standard therapy has been falling, necessitating ongoing efforts to identify new drug targets. Due to their important role in chemotaxis and nutrient uptake, periplasmic binding proteins (pbps) represent potential targets for new antimicrobial agents.
T1 - crystallisation and preliminary crystallographic analysis of helicobacter pylori periplasmic binding protein yckk.
Feb 14, 2014 pylori antigens for the detection of antibodies in sera from patients with different gastric diseases.
Proteomic analysis, using a ph range of 3–10 and 5–8, was performed. The individual proteins were identified by quadrupole time-of-flight (q-tof) mass spectrometer and protein database search. Results: variation in spot patterns directed towards differential protein expression levels was observed between the strains.
Researchers at baylor college of medicine show that analysis of the proteomics, or all the protein data, from aggressive human cancers is a useful approach to identify potential novel therapeutic.
Pylori induces disease-specific protein expression in gastric epithelial cells. The aim of the present study was to characterize proteins differentially.
After staining and image analysis, spots of interest were isolated and subjected to mass spectrometry. Results: seven proteins, which were up-regulated in h pylori-treated hepg2 cells, were identified. These proteins included integrin beta-1, protein kinase c alpha, lim/ homeobox protein lhx1, eif-2-beta, map kinase kinase.
) pylori is an important risk factor for gastric malignancies worldwide.
Global proteomic analysis and profiling assays using of thermo's newest mass spectrometer, the q-exactive hf-x allows id and accurately measure hundreds.
Helicobacter pylori inhabits the stomach mucosa and is a causative agent of stomach ulcer and cancer. In general, bacteriophages (phages) are strongly associated with bacterial evolution, including the development of pathogenicity.
Analysis of the obtained list of scf regulated proteins by cytoscape revealed a high degree of interconnectivity. When working in not yet or just recently-sequenced organisms, data bases might not contain the complete set of protein descriptions.
Comparative proteomics analysis of chronic atrophic gastritis: changes of protein expression in chronic atrophic gastritis without helicobacter pylori infection. Author information: (1)department of gastroenterology and hepatology, the 309 hospital of people's liberation army, beijing, china.
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This website contains 236 helicobacter pylori genomes (show list) and associated metabolic pathways. This site is part of the larger biocyc collection of thousands of pathway/genome databases for sequenced genomes.
Aim: the main objective of this study was to use high throughput approach to epithelial cells, mass spectrometry, helicobacter pylori, proteomic analysis.
Proteomics-based identification and analysis of proteins associated with helicobacter pylori in gastric cancer.
Increasing evidence shows that protein phosphorylation on serine (ser), threonine (thr) and tyrosine (tyr) residues is a major regulatory post‐translational modification in the bacteria. To reveal the phosphorylation state in the gram‐negative pathogenic bacterium helicobacter pylori, we carried out a global and site‐specific phosphoproteomic analysis based on tio2‐phosphopeptide.
Comparative proteomics analysis of chronic atrophic gastritis: changes of protein expression in chronic atrophic gastritis without helicobacter pylori infection. Department of gastroenterology and hepatology, the 309 hospital of people’s liberation army, beijing, china.
Functional analysis of the helicobacter pullorum n-linked protein glycosylation system adrian j jervis2,†, alison g wood3,†, joel a cain4, jonathan a butler5, helen frost6, elizabeth lord6, rebecca langdon7, stuart j cordwell4, brendan w wren7, and dennis linton6,1.
Antibody microarray based technology is a powerful emerging tool in proteomics, target discovery, and differential analysis. Here, we report the first study where recombinant antibody fragments have been used to construct large scale antibody microarrays, composed of 127 different antibodies against mostly immunoregulatory antigens.
Structural analysis of hypothetical proteins from helicobacter pylori: an approach to estimate functions of unknown or hypothetical proteins sung jean park 1,†, woo sung son 2,† and bong-jin lee 3,* 1 college of pharmacy, gachon university, 534-2 yeonsu 3-dong, yeonsu-gu, incheon 406-799, korea; e-mail: psjnmr@gachon.
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This site includes extensive retrieval, visualization and analysis tools: helicobacter pylori 26695 genome browser; helicobacter pylori 26695 metabolic map diagram; analyze gene expression, metabolomics, and chip-chip data; sequence searching and alignment for helicobacter pylori and other microbial genomes.
6-kilodalton protein is an iron-containing protein resembling ferritin. From genes to genome biology: a new era in helicobacter pylori research.
Proteomics-based identification and analysis of proteins associated with helicobacter pylori in gastric cancer plos one 2016 jan 8;11(1):e0146521.
The study of protein interactions constitutes an important domain to understand the physiology and pathogenesis of microorganisms. The two-dimensional blue native/sds-page was initially reported to analyze membrane protein complexes. In this study, both cytoplasmic and membrane complexes of a bacterium, the strain j99 of the gastric pathogen helicobacter pylori, were analyzed by this method.
Comparative analysis of two helicobacter pylori strains using genomics and mass spectrometry-based proteomics front microbiol 2016 nov 11;7:1757.
Structural and mutational analysis of tena protein (hp1287) from the helicobacter pylori thiamin salvage pathway evidence of a different substrate specificity giuseppe zanotti hp1287 (tena) from helicobacter pylori is included among the genes that play a relevant role in bacterium colonization and persistence.
Helicobacter pylori is a causative organism of various gastrointestinal diseases, including chronic gastritis, gastric ulcer, or gastric.
Proteomics analysis revealed that crosstalk between helicobacter pylori and streptococcus mitis may enhance bacterial survival and reduces carcinog enesis.
Herein, we report that integration of in-house metalloproteomics and quantitative proteomics allows comprehensive uncovering of the bismuth-associated proteomes, including 63 bismuth-binding and 119 bismuth-regulated proteins from helicobacter pylori, with over 60% being annotated with catalytic functions.
Helicobacter pylori is a pathogenic bacterium that has the remarkable ability to withstand the harsh conditions of the stomach for decades. This is achieved through unique evolutionary adaptations, which include binding lewis b antigens found on the gastric epithelium using the outer membrane protein baba.
Analysis of caga mrna and protein expression after transfection. 1, wt-caga plasmid and pr-caga plasmids for 36 h, respectively. (a) the rt-pcr analysis was used to detect caga mrna in the transformed cells. (b) western blot analysis was used to detect caga protein expression after transfection.
) pylori is an important risk factor for gastric malignancies worldwide. Its outer membrane proteome takes an important role in colonization of the human gastric mucosa.
Among 1590 orfs in the helicobacter pylori genome, 250 have been identified as authentic genes by proteomic analysis. Low‐abundance proteins need to be enriched to a minimal amount for maldi‐tof analysis and salt precipitation has generally been used for protein enrichment.
The 2-de/ms analysis with urea-solubilized proteins and the 1-de-lc/ms analysis with the urea-insoluble protein fraction (pellet) are complementary procedures in the pursuit of a complete proteome.
Proteomic analysis of a ferric uptake regulator mutant of helicobacter pylori: regulation of helicobacter pylori gene expression by ferric uptake regulator and iron.
Atrophic autoimmune gastritis (aag) is a condition of chronic inflammation and atrophy of stomach mucosa, for which development can be partially triggered by the bacterial pathogen helicobacter pylori (hp). Hp can cause a variety of gastric diseases, such as duodenal ulcer (du) or gastric cancer (gc). In this study, a comparative proteomic approach was used by two-dimensional fluorescence.
Systematic site-directed mutagenesis of the helicobacter pylori cagl protein of the cag type iv secretion system identifies novel functional domains.
Pylori infection is associated with chronic gastritis, gastric and duodenal ulcers, and malignant neoplasms.
Helicobacter pylori, previously known as campylobacter pylori, is a gram-negative, microaerophilic, spiral (helical) bacterium usually found in the stomach. Its helical shape (from which the genus name, helicobacter, derives) is thought to have evolved in order to penetrate the mucoid lining of the stomach and thereby establish infection.
Helicobacter cysteine-rich proteins (hcp) consist of several slrs that are cross-linked by disulfide bridges and have been implicated in host/pathogen interactions. Using pull-down proteomics, several human proteins including nek9, hsp90, and hsc71 have been identified as putative human interaction partners for hcpc.
Comparative proteomics analysis of chronic atrophic gastritis: changes of protein expression in chronic atrophic gastritis without helicobacter pylori infections march 2012.
Bioinformatic analysis of helicobacter pylori caga protein through motif search 9 and accessibility prediction v o l 75, 2007 c ag a -i n d u c terial pathog family g t pa infection with presence of a activation re activity of c d figure 1 results of helicobacter pylori infections on gastric epithelial cell [bou07], left to right, uninfected.
The human gastric pathogen helicobacter pylori is a paradigm for chronic bacterial infections. Its persistence in the stomach mucosa is facilitated by several mechanisms of immune evasion and immune modulation, but also by an unusual genetic variability which might account for the capability to adapt to changing environmental conditions during long-term colonization.
Helicobacter pylori is a bacterium recognized as the major cause of peptic ulcer and chronic gastritis.
Pylori clinical isolates derived from patients of two russian regions (moscow/moscow region and novosibirsk) were.
Among 1590 orfs in the helicobacter pylori genome, 250 have been identified as authentic genes by proteomic analysis. Low-abundance proteins need to be enriched to a minimal amount for maldi-tof.
Nov 10, 2020 standardised and reproducible analysis of mass spectrometry-based single-cell proteomics data.
Analysis of growth phase-dependent proteome profiles reveals differential regulation of mrna and protein in helicobacter pylori.
Helicobacter pylori proteomics was started with the aim to understand the protein composition of a bacterium containing a relatively small genome and to find immunologically relevant proteins the genome of the two strains 26695 ( 2 ) and j99 ( 3 ) has been sequenced completely, and gene annotation has revealed about 1,500 genes for each of them.
Pylori, it's an opportunistic bug meaning if you're under stress so we know how important the stomach is for breaking down protein.
Pylori reveals that bacterial growth stage affects the size, composition, and selection of protein cargo into omvs. Pylori omvs is vastly different throughout bacterial growth and that omvs contain a range of proteins compared to their parent bacteria.
Pylori infection can cause a range of digestive symptoms but not system which allows the bacterium to inject the caga protein into the host.
Pylori protein spots on two-dimensional (2-d) immunoblots probed with igg in sera from children. Pylori suitable for serological proteome analysis, cell lysate samples of three japanese strains, hpk5, cpy2052, and cpy3401, as well as two western strains, 26695 and ntct11637, were subjected to sds-page analysis followed by immunoblotting with.
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