Document Type: Article All Authors / Contributors: Sawyer G.M.; Sutherland-Smith A.J. ISSN:0022-2836 Language Note: English Unique Identifier: 820171585 Awards:
| Title | : | Crystal structure of the filamin N-terminal region reveals a hinge between the actin binding and first repeat domains |
| Author | : | Sawyer G.M.; Sutherland-Smith A.J. |
| Language | : | en |
| Rating | : | 4.90 out of 5 stars |
| Type | : | PDF, ePub, Kindle |
| Uploaded | : | Apr 12, 2021 |
Read Online Crystal structure of the filamin N-terminal region reveals a hinge between the actin binding and first repeat domains - Sawyer G.M.; Sutherland-Smith A.J. | ePub
Related searches:
The Filamin A Actin Binding Domain Structure and Function
Crystal structure of the filamin N-terminal region reveals a hinge between the actin binding and first repeat domains
Crystal Structure of the Filamin N-Terminal Region Reveals a
Structure of three tandem filamin domains reveals auto‐inhibition of
RCSB PDB - 2W0P: Crystal structure of the filamin A repeat 21
RCSB PDB - 2BRQ: Crystal structure of the filamin A repeat 21
(PDF) Crystal Structure of the Filamin N-Terminal Region
Crystal structure of the filamin A repeat 21 complexed with
The Molecular Basis of Filamin Binding to Integrins and
(PDF) Structure of three tandem filamin domains reveals auto
How does the interactio between the Filamin A repeat 10
RCSB PDB - 2J3S: Crystal structure of the human filamin A Ig
Crystal structure of the dimerization domain of human filamin
RCSB PDB - 2WA5: Crystal structure of human filamin B actin
Disease-associated Substitutions in the Filamin B Actin
Structural Study of the WH2 Family and Filamin - DiVA portal
Crystal structure of the dimerization domain of human filamin A.
(PDF) Structure of the human filamin A actin-binding domain
(PDF) Structure of filamin A immunoglobulin-like repeat 10
Structure of filamin A immunoglobulin-like repeat 10 from
(PDF) Crystal Structure of Human Filamin C Domain 23 and
Filamin structure, function and mechanics: are altered filamin
Molecular Basis of Filamin A-FilGAP Interaction and Its Impairment
Structural Basis of the Migfilin-Filamin Interaction and
Deciphering the Role of Filamin B Calponin-Homology - MDPI
Flexible Structure of Peptide-Bound Filamin A Mechanosensor - JYX
Mutations in the Gene Encoding Filamin A as a - AHA Journals
Molecular Tuning of Filamin A Activities in the Context of - Frontiers
The Calcium Fluorite ceramic (Ionic) crystal structure - YouTube
Structure and function of bacterial cytomotive filaments
Structural basis of the filamin A actin-binding domain
Structural Basis for Vertebrate Filamin Dimerization: Structure
Filamin A interaction with GPIbα: the platelet shapes up
The structure of the GPIb–filamin A complex Blood
Filamin - Proteopedia, life in 3D
Skeletal dysplasias due to filamin A mutations result from a gain-of
Filamins in Mechanosensing and Signaling Annual Review of
Filamin A: key actor in platelet biology Blood American Society of
HspB1 phosphorylation regulates its intramolecular dynamics and
Model of a Six Immunoglobulin-Like Domain Fragment of Filamin
PDB 2jf1 structure summary ‹ Protein Data Bank in Europe
(PDF) Structural Basis for Vertebrate Filamin Dimerization
PDB 2brq structure summary ‹ Protein Data Bank in Europe
Filamins: promiscuous organizers of the cytoskeleton: Trends
Expression, crystallization and preliminary crystallographic
524 3270 752 1630 4594 219 2777 4905 3977 1360 359 6 94 1231 2738 680 4053 4586 1857 1921 2639 4737 830 784 2156 2495 3784 305 2498 197 3875 4509 1057
2: mincd co-crystal structure suggests mincd together form a new class of alternating copolymeric cytomotive filament.
Sep 18, 2019 crystal structures- miller indices- semiconductor materials- silicon bonding - diamond lattice structure- silicon microprocessor.
Human filamins are large actin-crosslinking proteins composed of an n-terminal actin-binding domain followed by 24 ig-like domains (igflns), which interact with numerous transmembrane receptors and cytosolic signaling proteins.
Here, we report the crystal structure of a filamin-integrin interface. The structure, along with nmr titration and mutagenesis, reveals the basis for integrin-flna interactions, identifies potential means for regulation of this interaction, and suggests a general mechanism for the binding of igfln domains to their partners.
Crystal structure of the filamin a repeat 21 complexed with the integrin beta7 cytoplasmic tail peptide (2brq).
As a member of the wwpdb, the rcsb pdb curates and annotates pdb data according to agreed upon standards. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
Filamin a, alpha (flna) is a protein that in humans is encoded by the flna gene contents.
Crystal structure confirms this prediction: cys1912 is in direct hydrophobic contact with gpibα residue leu567, while cys1920 is located sufficiently close to the interface for its modifications to affect binding both of these cys residues are conserved in all 3 human isoforms of fln.
Filamin a (flna) is a large dimeric protein that binds to actin filaments via its actin-binding domain (abd). The domain adopts a closed conformation typical of other abds, but also forms a dimer both in crystallization conditions and in solution.
Nov 26, 2020 abstract: filamins (fln) are a family of actin-binding proteins involved in disturbance: insights from the crystal structures of filamin b actin.
Sawyer gm, clark ar, robertson sp, sutherland-smith aj (2009) disease-associated substitutions in the filamin b actin binding domain confer enhanced actin binding affinity in the absence of major structural disturbance: insights from the crystal structures of filamin b actin binding domains.
Seok and others published crystal structure of the dimerization domain of human filamin a find, read and cite all the research you need on researchgate.
Absence of major structural disturbance: insights from the crystal structures of filamin b actin binding domains.
Crystal structure of the filamin n-terminal region reveals a hinge between the actin binding and first repeat domains.
The crystal structure of the n-terminal region of filamin b, containing the actin binding domain (abd) and the first filamin repeat (fr1) domain, reveals an extended two-domain conformation with no interaction between the abd and fr1 other than the connecting linker region.
Filamins are essential, evolutionarily conserved, modular, multidomain, (a) crystal structure of spycas9 (surface representation) in complex with sgrna.
The complex structure of flna domain 21 and peptide from integrin β cytoplasmic tail shows that the peptide binds to the β‐strands c and d of filamin domain. 13 complex structure of flna domain 17 (flna17) and glycoprotein ibα (gp ibα) tail also shows that the binding partner interacts with filamin similarly.
Ig10 is a member of the class d filamin ig repeats, a class that also includes ig6, ig7, ig13 and ig14. The flna-ig10 crystal structure represents the first structure of a class d ig repeat from flna. Nmr structures of ig10, ig13 and ig14 from the flnb isoform have previously been solved by the riken structural genomics consortium.
Taken together, quantified by densitometry and filamin bound was calculated as these nmr experiments give strong support to the interaction the ratio of filamin bound to filamin in the loading control in each experiment (mean7s. Of the n-terminus of igflna20 with the cd face of igflna21 as seen in the crystal structure.
Crystal structure of the actin-binding region of utrophin reveals a head-to-tail dimer. Insights from the crystal structures of filamin b actin binding domains.
Muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as legend: helixturnbeta strandpdb structure known for this area.
Filamin a is a homodimeric protein consisting of an approximately 280-kda subunit, comprising an actin-binding domain at the n-terminus, followed by 24 immunoglobulin-like repeats, with the dimerization site at the ultimate c-terminal domain.
Crystal structure of igflna19–21 reveals unexpected domain arrangement. To study the domain arrangement of the major integrin‐binding site within filamin,.
Crystal structures of fln domains 4 and 5 in complex with the peptide revealed a typical β sheet augmentation interaction observed for many fln ligands.
Our recent crystal structure revealed that based on the crystal structure of igflna19–21 (protein data structureofigflna16–17andigflna18–19.
The crystal structure of the n-terminal region of filamin b, containing the actin binding domain (abd) and the first filamin repeat (fr1) domain, reveals an extended two-domain conformation with.
Jan 27, 2011 filamin structures exhibit a large radius of gyration in which the flexible insights from the crystal structures of filamin b actin binding domains.
Crystal coordinates of dictyostelium filamin deposited in protein. Data bank model construction was performed by the protein structure modeling program.
Crystal structure of igflna19–21 reveals unexpected domain arrangement. To study the domain arrangement of the major integrin‐binding site within filamin, we crystallized a fragment containing human flna domains 19–21 (igflna19–21). 5 å resolution were used for the crystallographic calculations.
Each monomer chain of filamin comprises an actin-binding domain, and a rod segment consisting of six (dictyostelium filamin) up to 24 (human filamin) highly homologous repeats of ∼96 amino acid residues, which adopt an immunoglobulin-like fold.
We have determined high-resolution x-ray crystal structures of the human filamin b wild type abd, plus w148r and m202v mutants. All three structures display the classic compact monomeric conformation for the abd with the ch1 and ch2 domains in close contact.
Oct 11, 2016 one structure positions the anions in the cube corner positions and in a simple cubic lattice with cations occupying half of the simple cubic.
Schematic representation of monomeric filamin a illustrating its general structure and the binding location of partners involved in actin.
Header cell adhesion 20-aug-08 2w0p title crystal structure of the filamin a repeat 21 complexed with title 2 the migfilin peptide compnd mol_id: 1; compnd 2 molecule: filamin-a; compnd 3 chain: a, b; compnd 4 fragment: ig-21, residues 2236-2329; compnd 5 synonym: alpha-filamin, filamin-1, endothelial compnd 6 actin-binding protein, actin-binding protein 280, compnd 7 abp-280, nonmuscle.
Crystal structure of the filamin a repeat 21 complexed with the integrin beta7 cytoplasmic tail peptide.
The crystal structure of filamin a domains 19–21 (flna19–21) revealed that domains 20 and 21 fold together and that the domain interaction can be autoregulatory. The solution structure of domains 18–19 showed a similar domain interaction, whereas domain pair 16–17 has a completely different domain packing mode.
Crystal structure of human filamin c domains 4-5 and gpib alpha cytoplasmic domain complex: heteromer p07359; 4mgx: assess solution nmr structure of the filamin.
Research papers acta crystallographica section d biological structure of the human filamin a actin-binding crystallography domain issn 0907-4449 salla ruskamo* and jari yla¨nne filamin a (flna) is a large dimeric protein that binds to actin received 24 june 2009 accepted 15 september 2009 filaments via its actin-binding domain (abd).
Into the structure and mechanism of actin binding domains, and thus provide a better understanding of the diseases caused when this domain is mutated. A secondary structural analysis and crystal structures of the wildtype and opd2 associated mutant abds were obtained.
Aug 31, 2015 structure factors for the crystal structure are available domain followed by a string of 24 filamin immunoglobulin domains (igflns), typically.
Swiss-model repository entry for p21333 (flna_human), filamin-a.
Crystal structure of human filamin c domain 23 and small angle scattering model for filamin c 23–24 dimer.
The quality of the data indicates the possibility of solving the structure of filamin a repeats 14–16 by molecular replacement using the crystal structure of domain 24 of human filamin c (pdb code 1v05) as a start model in a multicopy search.
Crystal structure of the filamin a repeat 21 complexed with the integrin beta2 cytoplasmic tail peptide.
May 22, 2019 mutations in the actin-binding protein filamin c (flnc) are linked to 3 crystal structure of the hspb1 acd in complex with a partial peptide.
Post Your Comments: