Read The pattern of the descent of PTH measured by intraoperative monitoring of intact-PTH in surgery for renal hyperparathyroidism. - M Echenique-Elizondo Affiliation: Department of Surgery, Basque Country University, Bilbao, Spain.; FJ Díaz-Aguirregoitia; JA Amondarain; F Vidaur | PDF Online

Read The pattern of the descent of PTH measured by intraoperative monitoring of intact-PTH in surgery for renal hyperparathyroidism. - M Echenique-Elizondo Affiliation: Department of Surgery, Basque Country University, Bilbao, Spain.; FJ Díaz-Aguirregoitia; JA Amondarain; F Vidaur file in ePub

Document Type: Article All Authors / Contributors: M Echenique-Elizondo Affiliation: Department of Surgery, Basque Country University, Bilbao, Spain.; FJ Díaz-Aguirregoitia; JA Amondarain; F Vidaur ISSN:0972-2068 Language Note: English Unique Identifier: 816516419 Awards: Abstract: BACKGROUND: In the setting of total parathyroidectomy and autotransplantation surgery (TPTxAS) treatment for secondary hyperparathyroidism (SHPT) we evaluated whether intraoperative parathyroid hormone (iPTH) monitoring is an useful tool as a reference for total parathyroid removal. DESIGN: Prospective open single value measurement efficacy study of one intraoperative (i.o.) diagnostic monitoring method (iPTH) on a cohort of surgical patients. PATIENTS: All patients (n = 35) undergoing TP and SCTx at the Department of Surgery, Donostia Hospital from January 2002 to December 2006. MAIN OUTCOME MEASURES: Serum levels of iPTH during surgery and prediction time of the of descent of PTH levels (measured in the clinic, at admission day and intra-operatively during induction of anesthesia, and every 5 and 10 minutes after removal of adenoma and 24 hours thereafter) were analyzed. RESULTS: iPTH levels dropped clearly at ten minutes in all 35 patients and were non-measurable at 24 hours. iPTH decreased from pathological (1302.24 424.9 pg/ml) to half (50%) the values at the third intra-operative determination - minute 10 - (614.8 ± 196.62) and was undetectable at 24 hours. CONCLUSIONS: Intra-operative measurement of iPTH is useful in the prediction of complete removal of all parathyroid tissue prior to autotransplantation thus avoiding persistence because of incomplete surgery.

Title : The pattern of the descent of PTH measured by intraoperative monitoring of intact-PTH in surgery for renal hyperparathyroidism.
Author : M Echenique-Elizondo Affiliation: Department of Surgery, Basque Country University, Bilbao, Spain.; FJ Díaz-Aguirregoitia; JA Amondarain; F Vidaur
Language : en
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Type : PDF, ePub, Kindle
Uploaded : Apr 12, 2021

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